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Role of Porcine Coronary Artery Endothelium in the Realization of Contractile Effect of Acetylcholine. Pp. 94–101.

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Section: Biology

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Authors

Chulkina Elena Aleksandrovna, Natural Geography Faculty, Vyatka State Humanities University; Postgraduate Student, Department of Pediatrics, Kirov State Medical Academy (Kirov, Russia) 

Tsirkin Viktor Ivanovich, General Medicine Faculty, Kazan State Medical University (Kazan, Russia)

Abstract

The contractile response of 476 ring segments of porcine coronary artery was investigated. Endothelial damage does not alter myocyte contractility but reduces the probability of observing and the severity of their constriction response to acetylcholine (10-10, 10-9, 10-8, 10-5 g/ml), increases probability of observing their dilatation response, without changing its expression. Endothelium contributes to the efficiency of activation of M1-, M2- and M3-choline receptors (ChR) of myocyte-constrictors, without affecting the efficiency of activation of M4-ChR myocyte-dilatators.

Keywords

coronary artery, acetylcholine, endothelium, M-choline receptors.

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